Macro-F1 and AMI scores computed based on manually annotated TCNs. Each data point represents the performance on one image; the horizontal bars represent the mean across n = 3 images. Performances (points) on the same image are connected by gray dashed lines. P values were computed using a one-sided paired t -test. Note that only UTAG identified seven TCNs in the BALB/c-3 image, while all other methods identified four TCNs in all three images. mphs, macrophages; DNT, TCRalpha + CD4 - CD8 - double-negative T [cell]; NS, not significant.
