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Schematic of maraviroc (MVC) treatment in HD mouse model. MVC (50 mg/kg B.W.) was administered daily via i.p. injection to a mixed cohort of single (n=2HD:Ccr5+/+) and double (n = 6 HD:Ccr5+/+: Tfl+/−) transgenic mice and control mice (n = 4Ccr5+/+: Tfl+/−) aged 8 weeks. An equal number of single and double transgenic and control mice were daily injected with vehicle. After 28 days, mice were perfused in paraformaldehyde (PFA) and brains were collected and processed for histological analyses shown in (E), (F), (G), and (H).
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