Microscopy from Scientific Research

Representative image of a case with spare (left panel) and high (right panel) NFT density. Top left images show tau AT8 immunoreactivity by immunohistochemistry and the inset highlights the presence of NFTs. At top right is a maximum-intensity projection of 12 consecutive 70-nm-thick sections by array tomography microscopy. Presynaptic synaptophysin-positive terminals (magenta) and oligomeric tau (T22, yellow) are shown. The inset highlights the presence of presynaptic terminals with oligomeric tau that are pointed by arrowheads in the horizontal panel of four consecutive 70-nm-thick sections.

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