Network from Scientific Research

Bioinformatic identification and phylogenetic tree of ~3,000 predicted cGLRs from nearly all major animal phyla. Characterized cGLRs including vertebrate cGAS proteins, N. vectensiscGLR, and Drosophila cGLR1 are denoted with an orange star. cGLRs with published crystal structures are denoted with a green triangle at the tree edge. Closely related Mab21L1/2/3 genes are included but do not contain a predicted functional active site. Yellow circles represent cGLRs cloned for the biochemical screen, and purple circles denote active cGLRs selected for in-depth analysis. For additional information, see Figure S3 and Table S1.

DOI