Illustration from Scientific Research

The interactive residues of L5.34 and L4.65 footprints on SARS-CoV-2 RBDs (prototype, Omicron BA.2 and Omicron BA.4/5). Cells colored in blue or pink represent the residues involved in the antibody interaction. Red characters highlight the mutated residues on the RBD of BA.2 or BA.4/5. Sequence conservation of the interactive residues of L5.34 and L4.65 footprints from 122,413 SARS-CoV-2 sequences randomly selected from the GISAID database representing the virus strains from Jan 2020 to Jan 2023. Sequence Logo plots illustrate the amino acid distributions at each interactive residue. Letter height represents frequencies of amino acid in dataset.

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