Illustration from Scientific Research

Upper panel: footprints of representative benchmark antibodies from each antigenic site (RBD-1 to RBD-8) mapped onto a prototype SARS-CoV-2 RBD are highlighted in color. Structure models used for benchmark antibodies are as follows: CV30 (PDB: 6XE1); REGN-10933 (PDB: 6XDG); CV07-270 (PDB: 6XKP); C110 (PDB: 7K8V); COVA1-16 (PDB: 7JMW); CR3022 (PDB: 7JN5); S2H97 (PDB: 7M7W). The expected footprint of ADI-56046 was drawn as previously described 46 . RBM for hACE2 (PDB: 6LZG) is outlined with black lines. Bottom panel: antigenic sites of bnAbs grouped into clusters according to competition profile to eight benchmark antibodies (related to Supplementary Fig. S4 ).

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