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HCV infection upregulates FUT8 protein expression through EGFR-AKT-SNAIL axis, and promotes EGFR core fucosylation and EGFR/STAT3 phosphorylation. The aberrant increased-FUT8 expression promotes Trim40 to associate with RIG-I, leading to K48-linked ubiquitination and proteasomal degradation of RIG-I, which suppresses RIG-I-triggered IFN-I production in the innate immune response. The figure is created with Biorender.com.

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