Representative images of the expression in cortex, thalamus, caudate nucleus, putamen, hippocampus and claustrum after IV administration of 1 x 10 14 vg kg - 1 of an eight-capsid pool (1.25 x 10 13 vg kg - 1 of each variant) packaging HA-tagged human frataxin with a unique barcode in each capsid. HA epitope expression in the cortex and hippocampus is observable in single cells with clear projections that resemble the apical dendrites of pyramidal cells. Furthermore, the thalamus and dorsal striatum contain areas of dense HA expression relative to other brain regions. The white dashed line signifies the difference between viral DNA and whole RNA sections of the plot.
