Protein Structure from Scientific Research

Overview of design of allosteric sites in E. hirae V1-ATPase. The active sites in the catalytic interface and the pseudo-active sites in the non-catalytic interfaces are indicated by solid and dashed arrows, respectively, in the hexameric ring of V1 consisting of A subunits (cyan) and B subunits (pink). The rotor of the D and F subunits (grey) is located in the centre of the ring. The pseudo-active sites in the non-catalytic interfaces are designed to be ATP-binding allosteric sites that control the ATP hydrolysis function of the active sites in the catalytic interfaces.

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