The ROPS determined sensory and affective pain measured with the MPQ, anxiety and depressive mood ( n ROPS:0 = 13, n ROPS:1 = 29, n ROPS:2 = 12, n ROPS:3 = 22, n ROPS:4 = 8 and n ROPS:5 = 2). Box plots show the medians and are bound by the first and third quartiles. Data points outside 1.5 interquartile range are shown as diamonds. PAO in both replication cohorts was defined as pain in five or more sites. The 95% CI was estimated across 1,000 bootstrap samples ( c , e , g ). In boxplots, the center line (median), white dot (mean), box (inner quartiles), whiskers (bottom and top bounds) and diamonds (outliers outside 1.5 interquartile range) are shown. MSK, musculoskeletal. *Longitudinal data had a different n than the whole sample.