The score effect sizes relative to the effect size of GPS 2018 in European ancestry individuals. '>3-fold larger CAD GWAS' designates a polygenic score generated using summary statistics of largely European ancestry from the most recent CARDIOGRAMplusC4D excluding the UK Biobank (GPS CADEUR ). 'Multi-ancestry CAD GWAS' refers to the polygenic score generated by combining ancestry-specific polygenic scores generated using GWAS summary statistics from CARDIOGRAMplusC4D, Genes & Health, Biobank Japan, Million Veteran Program and FinnGEN biobanks in layer 1 (GPS CADANC ). GPS Mult designates polygenic score for CAD designed with summary statistics from multiple ancestries and multiple CAD-related traits in layer 2. Asterisk designates the reference group for calculating relative gain.
