Forest Plot from Scientific Research

Adjusted HR/SD of the polygenic score with corresponding 95% CIs and P values for incident CAD by ancestry, stratified by the version of the polygenic score, calculated from Cox proportional-hazards regression models adjusted for age, sex, genotyping array and the first ten principal components of ancestry in the UK Biobank validation dataset, consisting of n = 7,157 independent individuals of African ancestry, n = 1,442 independent individuals of East Asian ancestry, n = 297,772 independent individuals of European ancestry, and n = 8,440 independent individuals of South Asian ancestry. GPS 2018 corresponds to a previously published polygenic score for CAD 9 . P values are derived from a Wald test implemented in the coxph function in R and are two-sided.

DOI