Scatter Plot from Scientific Research

The OR/SD with 95% CI for prevalent CAD risk was assessed for each polygenic score in a logistic regression model adjusted for age, sex, genotyping array and the first ten principal components of ancestry in the same group of individuals per cohort: n = 33,096 independent African ancestry individuals in the Million Veteran Program; n = 124,467 independent European ancestry individuals in the Million Veteran Program; n = 16,433 independent Hispanic ancestry individuals in the Million Veteran Program; n = 16,874 independent South Asian ancestry individuals in the Genes & Health Study, using high-performing published scores from the Polygenic Score Catalog (GPS 2018 (ref. 9 ), metaGRS 8 , metaPRS CAD 67 , AnnoPred CAD 68 , PRSCS CHD 69 and PRS 2022 (ref. 27 ), as well as GPS Mult 28 . Results for these and additional CAD polygenic scores published in the Polygenic Score Catalog are available in Supplementary Tables 6 and 7 .

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