Microneutralization of live ancestral or omicron BA.1 SARS-CoV-2 at the post-V2 timepoint ( h ). Correlation of microneutralization IC 50 with ancestral anti-SARS-CoV-2 RBD-binding total Ig ( g ) and microneutralization IC 50 separated by previous SARS-CoV-2 infection status. d , e , g , h , n = 59 participants selected from liver and inflammatory disease groups with anti-SARS-CoV-2 RBD total Ig above 250 AU ml -1 . Paired statistical comparisons among multiple groups ( d – f , h ) were assessed using two-sided Friedman’s test with Dunn’s correction or Wilcoxon’s rank-sum test with Bonferroni correction. Unpaired statistical comparisons among multiple groups were assessed using two-sided Mann–Whitney U -test with Bonferroni correction. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
