Anti-SARS-CoV-2 spike RBD total Ig responses separated by vaccine type. Statistical comparison of vaccine type in each disease group is presented. Unpaired statistical comparison was made on all groups using a two-sided Kruskal Wallis with post hoc Dunn’s testing. Comparisons of proportions were performed using 2 or Fisher’s exact tests adjusted for significance using Bonferroni correction (adjusted alpha = 0.003). Only significant comparisons are presented. * indicates statistically significant by Bonferroni-adjusted alpha. Boxes represent median and IQR; whiskers represent ±1.5 IQR. AAV, ANCA-associated vasculitis; CD, Crohn’s disease; HC, healthy controls; HD, hemodialysis; HD on IS, hemodialysis on immunosuppression; HM, hemotological malignancy; IA, inflammatory arthritis; L-AI, autoimmune hepatitis; L-Cir, liver cirrhosis; L-Tr, liver transplant; SC, solid cancer; UC, ulcerative colitis.