Principal coordinate analysis of the Euclidean distance matrix reflecting cross-validated pairwise differences in regional mutation frequencies between NSCLC, SCLC and HCC. The first two principal coordinates are shown with contours indicating kernel density estimations for 0.7 and 0.95 probability for each cancer type. The composition of cancer types in clusters derived from K -means clustering with k = 3 is indicated to the right. All boxplots represent the interquartile range, with whiskers drawn to the highest value within the upper and lower fences (upper fence, 0.75 quantile + 1.5x interquartile range; lower fence, 0.25 quantile 1.5x interquartile range). The solid middle line in the boxplot corresponds to the median value.
