ROC curve for detection of high-risk individuals from the LUCAS cohort who were diagnosed with stage I lung cancer ( n = 13 with lung cancer, n = 74 without cancer) (left panel), stage I lung cancer among individuals in the validation cohort ( n = 25 with lung cancer, n = 14 without cancer) (middle-left panel), high-risk individuals from the LUCAS cohort with a ≥40 pack-year smoking history who were diagnosed with stage I lung cancer ( n = 9 with lung cancer, n = 46 without cancer) (middle-right panel) and stage I lung cancer among individuals with a ≥40 pack-year smoking history in the validation cohort ( n = 13 with lung cancer, n = 5 without cancer) (right panel). All boxplots represent the interquartile range, with whiskers drawn to the highest value within the upper and lower fences (upper fence, 0.75 quantile + 1.5x interquartile range; lower fence, 0.25 quantile – 1.5x interquartile range). The solid middle line in the boxplot represents the median value.
