Circos plot reflecting regions of top-mutated mSWI/SNF subunits and the local enrichment of missense and in-frame indel mutations in NDD (green), Cancer (red) or NDD-Cancer difference (represented as NDD-Cancer NES): NDD (orange) or cancer (purple); interactions between subunits, determined by cross-linking mass-spectrometry (CX-MS) performed on endogenous cBAF complexes are shown (NCP-bound endogenous cBAF, from Mashtalir et al. 93 ). Scaled local recurrence, and NDD-Cancer NES were calculated similarly to panel c with one exception, where all secondary paralog mutations were preserved instead of remapping to paralogs. Enrichment scores were bounded from 0 to 1 for local recurrence and -1 to 1 for differential enrichment of mutations. Domains are represented as darker bands in the first inner ring of the Circos plot.
