Cartoon representations of the four classes of chromatin remodelers (SWI/SNF, CHD, ISWI and INO80) and respective subcomplex or related complex associations, colored by CNV loss/SNV/indel variation frequency from panel c . Interchangeable subunit paralogs are colored by their combined mutational frequency. Autism spectrum disorder (ASD) risk score (SFARI) and developmental disorder associations curated from literature and OMIM (Online Mendelian Inheritance in Man, a catalog of human genes and genetic disorders; https://www.omim.org/ ) are indicated. Asterisk (*) indicates paralog implicated in NDD. Where possible, cartoons were based on 3D structural data available from human and yeast structures; ovals are used in in lieu of structural cartoons for components lacking structural data.
