Volumetric quantification confirmed that WT cells replaced their HD counterparts as they expanded from their implantation site. Top row: H 1 , interaction of allografted WT versus HD cells, at 54 and 72 weeks. The advance of WT cells was accompanied by the progressive elimination of HD glia. P < 0.0001 at both 54 weeks ( n = 8 mice) and 72 weeks ( n = 7). Bottom row: H 2 , comparison of HD hGPCs exposed to WT cells (HD allograft; n = 8 at 54 weeks, n = 7 at 72 weeks) versus unchallenged HD cells (HD control; n = 4 at both timepoints); P < 0.0001 at each timepoint, two-way analysis of variance (ANOVA) with Sidak’s multiple comparisons tests. Data presented as means ± s.e.m.
