Workflow from Scientific Research

SCENIC+ workflow. Topics and DARs inferred with pycisTopic are transformed into cistromes of directly bound regions by identifying modules that present significant enrichment of the regulator’s binding motif using pycisTarget. SCENIC+ integrates region accessibility, TF and target gene expression and cistromes to infer eGRNs, in which TFs are linked to their target regions and these to their target genes. PWM, position weight matrix; UCSC, University of California, Santa Cruz.

DOI