Workflow from Scientific Research

Workflow to create motif databases for SCENIC+. The SCENIC+ motif collection includes 34,524 unique motifs gathered from 29 motif collections, which were clustered with a two-step strategy. Input regions are scored for each cluster of motifs using hidden Markov models (HMMs), where each motif of the cluster is used as a hidden state. The score-based motif database is used in the DEM algorithm, whereas the ranking-based database is used for cisTarget. NES, normalized enrichment score.

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