Illustration from Scientific Research

Strategy for transient repair pathway inhibition. Motifs or domains beneficial or detrimental for homologous recombination/HDR are colored green or rose, respectively. The amino acid positions where domains start and end are given, their functions indicated and the small-molecule inhibitor of the kinase domain of DNA-PKcs M3814 (ref. 76 ) and siRNAs targeting the POLQ mRNA are indicated in red.

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