Side-by-side boxplots of Euclidean distances between true and predicted locations for all cells in the test data for each method and scenario evaluated (Scenario 1: n cells in the test set = 29,770, 8872, 7097, and 8872 for CeLery, Tangram, SpaOTsc, and novoSpaRc respectively due to the computational capacity of each method; Scenario 2: n cells in the test set = 29,770 for each method; Scenario 3: n cells in the test set = 29,770, 8872, 7097, and 8872 for CeLery, Tangram, SpaOTsc, and novoSpaRc respectively due to the computational capacity of each method. In each boxplot, the lower and upper hinges correspond to the first and third quartiles, and the center refers to the median value. The upper (lower) whiskers extend from the hinge to the largest (smallest) value no further (at most) than 1.5 interquartile range from the hinge. Data beyond the end of the whiskers are plotted individually.