Survival Curve from Scientific Research

Mice were infected intranasally with 10 3 pfu of SARS-CoV-2 and monitored for survival and weight loss. CC x K18-hACE2 were classified as: a sensitive with 50% or greater mortality and no difference between males and females, b resistant with 35% or less mortality, or (c) sensitive with a sex bias as having statistically significant difference between male and female mice. Graphs of percent starting weight show the mean ± SD. Biological replicates were examined over at least 2 independent experiments and the numbers of mice assessed per strain (male: female) were as follows: (K18-hACE2 (7:7); A/J x K18-hACE2 (6:5); PWK x K18-hACE2 (6:6); NZO x K18-hACE2 (7:7); 129S1 x K18-hACE2 (7:8); CAST x K18-hACE2 (6:6); NOD x K18-hACE2 (6:6); WSB x K18-hACE2 (6:6). The Mantel-Cox log-rank test with 95% confidence interval was used to compare male versus female survival curves for each strain. * p < 0.05 was considered statistically significant.

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