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The solvent accessible surface area (SASA) (A 2 ) of wildtype and mutant protein of segments 1 ( A ) and 2 ( B ). For both segments, the SASA (A 2 ) of the mutant structure is higher than that of the wildtype one (Segment 1 wildtype: mean: 21,906.066 A 2 , SD: 282.987 A 2 ; mutant: mean: 22,675.036 A 2 , SD: 453.033 A 2 ; segment 2 wildtype: mean: 21,565.973 A 2 , SD: 245.14 A 2 ; mutant: mean: 22,160.942 A 2 , SD: 269.095 A 2 ). All the means and SD are calculated with values after 170 ns
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