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Mechanisms of probiotic protection of the host against pathogen infections. Dietary supplementation with Bacillus velezensis BV1704-Y induces an increase in the abundance of the indigenous gut microbiota (Cetobacterium) and thus metabolizes sufficient amounts of vitamin B 12. Vitamin B 12 is used by the surrounding microbiota to form a more stable and complex gut ecological network while reducing the redox potential in the gut and maintaining the anaerobic state of the intestinal lumen, which further promotes the expression of intestinal tight junction proteins (Claudin15 and Zo-1) and prevents the infestation of Aeromonas
#Illustration#Workflow#Probiotic Protection#Pathogen Infections#Bacillus Velezensis#Gut Microbiota#Vitamin B12#Ecological Network#Redox Potential#Intestinal Lumen#Tight Junction Proteins#Aeromonas
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