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The experimental design. (i) The zebrafish were fed a basic diet supplemented with/without vitamin B 12 (200 μg/kg diet per day) for 28 days (Group B/CK), respectively, and then bath infected with A. hydrophila strain at a concentration of 1 × 10 8 CFU/mL (Group TB/TCK). (ii) The zebrafish were fed a diet containing an antibiotic mix (120 mg/kg metronidazole, 120 mg/kg neomycin sulfate and 60 mg/kg vancomycin) for 7 days (Group AB/ACK), and then received the same treatments as (i) (Group TAB/TACK).

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