A proposed mechanism for substrate entrance and product release involving a drawing compass movement (inset) of TGP 2 (cPGAP1 S327A , magenta; cPGAP1 H443N , light pink). The 1-alkyl is shown in ball-and-stick representation. PLM (green) and cholesterol (CHL, yellow) are from cPGAP1 S327A . cPGAP1 is shown as a surface representation with the transmembrane (TM) domain in blue and the lipase domain in orange.
