Epiphany cross-species prediction of structural changes caused by CTCF perturbation. Epiphany was trained using human cell line GM12878, and predicted using mouse limb bud epigenomic data mapped relative to the mm10 assembly. The panel shows Epiphany prediction of WT mES Hi-C map with HiC-DC+ obs/exp ratio normalization (top row), the prediction of TAD fusion after masking CTCF sites at (mm10 chr11:111,520,000–111,540,000) (middle row), and the absolute difference between the two predictions (bottom row). Epigenomic tracks at the bottom are showing feature attribution (SHAP value) for highlighted vertical vector in the Hi-C contact map. The upper two tracks are the original CTCF track and corresponding SHAP values. The lower two tracks are CTCF tracks with peaks in the vertical line deleted and the corresponding SHAP values.
