Profile of somatic driver gene mutations in primary and relapse tumors. Oncoprint showing SNVs for selected driver genes (TP53, BRCA1, BRCA2, CCNE1, NF1, RB1, PTEN, BRAF, CTNNB1, BARD1, and PIK3CA) in each deposit from patients whose tumor samples showed some somatic SNVs affecting these genes. Samples (columns) are ordered by patient and additionally labeled with the corresponding patient’s relapse category, and whether the sample was taken at primary debulking surgery or at relapse. Presence of any SNVs is indicated by blue boxes. Most patients showed SNVs that were clearly either clonal (detected in all deposits) or sporadic (only detected in one deposit). Patient T16-046 is highlighted, because the PIK3CA SNV was detected in some, but not all, primary deposits but was also detected in the relapse tumor.
