Variation in exposure to HGSOC copy-number signatures. Boxplot showing the exposure levels of the seven copy-number signatures of HGSOC for 215 samples from 46 patients, grouped by relapse status. Kruskal-Wallis test was performed across samples from patients of different relapse status within each copy-number signature group. Statistical significance was observed for signatures 2 (related to poor overall survival, due to tandem duplication through CDK12 inactivation; p = 0.00021), 3 (related to favorable overall survival, mechanism of BRCA1/2-related HRD; p = 0.0011), 4 (related to poor overall survival, due to whole-genome duplication related to failure of cell-cycle control and phosphatidylinositol 3-kinase (PI3K) inactivation; p = 0.00047), and 6 (related to poor overall survival, mechanism proposed of focal amplification due to failure of cell-cycle control; p = 0.00032).
