Illustration of tumor evolution under distinct mutational processes. Stacked bar plot showing the CN signature exposures for primary and relapsed tumor samples from a patient who relapsed in a sensitive time frame. Samples are clustered using the CNEventDist, with colored branches of the dendrogram indicating each distinct clone estimated in this patient (T14-137). Blue text indicates tumor deposits collected from the primary surgery, and red text indicates tumor deposits collected from the corresponding relapse surgery. Distinct CN signature profiles can be observed in the primary tumor samples in which the samples from the ovary and omentum are similar and cluster together but are different from the samples from the rectum, diaphragm, and the right pelvic side wall, which form another cluster. Clonal origin estimation reveals the relapse samples evolving from the clone represented by the samples from the rectum, the diaphragm, and the right pelvic side wall.
