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Heterogeneous clustering patterns of tumor evolution for primary presentation cases based on inter-deposit CNEventDists. Dendrograms showing representative sympodial (left, case T17-046) and dichotomous (right, case T18-011) clustering patterns from two different primary cases. Each color shown on the dendrogram branches indicates a different clone. Bar chart (lower) showing the prevalence of the two different clustering patterns (topologies), grouped by relapse status; n = 43, because topology could not be determined for three patients. Fisher’s exact test, p = 0.03525.

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