Heterogeneous clustering patterns of tumor evolution with matched relapse samples based on inter-deposit CNEventDists. Representative dendrograms for three different clustering patterns for primary and relapse samples from the same patient. The dendrogram branches are again colored for different clones. Blue text indicates tumor deposits collected from the primary surgery, whereas red text indicates tumor deposits collected at relapse. Type 1 pattern (left) is those with monoclonality in the primary samples, and all relapse samples are from the same clone; type 2 (middle) is polyclonal primary samples and relapse samples originating from one or more of those clones; type 3 (right) shows monoclonality or polyclonality in the primary samples, and at least one relapse sample originates from a clone not present in the primary samples. Bar chart (lower) shows the prevalence of distinct evolutionary relapse patterns.
