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Scheme of Unc13A indicating the regulatory Ca2+/calmodulin binding (CaM) domain, the DAG/PMA binding C1 domain, the Ca2+/phosphoinositide binding C2B domain, the functionally essential MUN domain, and the C2C domain implicated in SV association. Note that, unlike in mammals and C. elegans, the N-terminal C2A domain is missing in Drosophila. Arrows point to the amino acid changes in the here-analyzed Unc13A CaMW1620R,W1622R (Unc13ACaMWRWR) mutant.
#Illustration#Unc13A#Ca2+/calmodulin binding (CaM) domain#DAG/PMA binding C1 domain#Ca2+/phosphoinositide binding C2B domain#MUN domain#C2C domain#SV association#C2A domain#Drosophila#Unc13A CaMW1620R,W1622R (Unc13ACaMWRWR) mutant
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