The heatmaps illustrate the estimated hazard ratios (HRs) for each cancer that is associated with a one-unit increase in the respective adiposity trait. All estimates are adjusted for year of birth, smoking, and 15 genetic principal components. The order of the adiposity traits corresponds to the clustering in females as illustrated inFigure 1. The coloring of the names corresponds to the clustering in females and males, where black color represents fat accumulation and green represents fat distribution. WHR in males clustered with fat accumulation traits, in contrast to females where WHR clustered with body fat distribution traits. Sex-interactions are highlighted with dark squares for traits with a significant interaction term in Cox proportional hazard modeling at 5% false discovery rate (FDR). In the lower panel, participants were stratified by smoking status (never, previous or current smoker) for a subset of the cancers. There were no incident cases among the current smokers with magnetic resonance imaging (MRI) data and these squares are therefore grayed out. Abbreviations: RCC = renal cell carcinoma, TCC = transitional cell carcinoma, HCC = HCC, CAC = cholangiocarcinoma, EAC = esophageal adenocarcinoma, ESCC = esophageal squamous cell carcinoma, SCLC = small cell lung carcinoma, NSCLC = non-small cell lung carcinoma. VAT-SAT ratio = visceral-to-subcutaneous adipose tissue ratio. WCadjBMI = WC adjusted for BMI. WHRadjBMI = WHR adjusted for BMI.*= significant at a nominal level of significance (P < 0.05).**= significant at 5% FDR. See alsoData S2,S3, andFigures S2–S4.
