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IL-6 production by untreated and IL-1β-stimulatedLkb1−/−MEFs transfected with siRNAs targeting the indicatedCrtc(1/2) orHdac(4/9). Non-targeting (Ctrl) and siRNA targetingMyd88were used as negative controls. siRNA targetingSocs3was used as a positive control. Statistical analysis compared IL-1β-treated siRNA knockdown to IL-1β-treated control (Ctrl) (mean ± SD, n = 3/group).
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