Illustration from Scientific Research

All functional subcomplexes form a defined and stable supercomplex. This study finds that the ATG9-13-101 complex is an interaction hub, whose assembly represents a rate-limiting intermediate due to the slow obligatory conversion between topologically distinct native folds of ATG13 and ATG101 (inset). The vesicle tethering and lipid transfer rate of ATG2 is enhanced when interacting with ATG9-13-101.

DOI