Normalized neurite outgrowth analysis of iPSC-MNs derived from familial ALS patients treated with vehicle, fatostatin (100 nM), atorvastatin (100 nM), and pitavastatin (1 nM) (gray: vehicle, pink: each drug) (error bands = mean SEM, n = 3 independent experiments, MANOVA test).*,**, and***represent statistical significance at p < 0.05, p < 0.01, and p < 0.001, respectively. SALS, sporadic amyotrophic lateral sclerosis; hMN, helathy control-derived iPSC-MN; pMN, participant-derived iPSC-MN; CTRaS, chemically transitional embryoid-body-like state; DEGs, differentially expressed genes; GO, gene ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; SEM, standard error of the mean.
