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Overlayed heatmap into the hematopoietic tree showing the fold expansion of TET2 mutations from HSCs. The following cell populations were analyzed (HSCs, MPP, CLP, CMP, GMP, B cells, monocytes, and HG and LN neutrophils). Data representative of 4 humanized mice. SeeFigure S7A for sorting strategy andFigure S7B for raw data of VAF for each cell population in each humanized mice.

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