Microscopy from Scientific Research

Images (a) and quantification (b) of cGAS and ISD90, or cGAS and human nucleosomal core particles (hNCP) colocalization in control cells and sg MRE11 MDA-MB-231 cells. Left to right, n = 344, 312, 491, 405, 366 and 243 independent cells. White arrowheads indicate colocalization of cGAS and ISD90 foci. WT versus sg MRE11 , ISD90, P = 0.007; hNCP, P = 0.0038. Scale bars, 20 m.

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