Line Plot from Scientific Research

Effect of CDK8 inhibitors (0.5 M, 48 h) on improving the differentiation efficiency under titration of CHIR concentrations using iPS-B1 line. CHIR was added with BI-1347, AS2863619, or MSC2530818 for 0–48 h. The widths of effective CHIR concentration (percentage of cTnT + cells 50%, indicates by a dashed line) were shown in the upper panel. Data are means SD. n = 3. Statistical significance was determined by t -test to compare the BI-1347, AS2863619, and MSC2530818 groups with the CTL group under each CHIR concentration. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001; ns, not significant.

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