Explained variance from a linear regression model of Big 5 personality and cognitive function (PGS) (r 2 , y axis) for top 10, 100, 1000, 10,000 and 100,000 independent variants using primary GWAS P value-based ranking (light orange), multitrait analysis of GWAS (MTAG, light blue) adjusted on UKB neuroticism (for personality traits) and fluid intelligence (for cognitive function) and pleiotropy-informed (pleioPGS) ranking (dark orange), alongside PRS-CS using all SNPs (blue) from 23andMe and CHARGE GWAS summary statistics, respectively. *Indicates statistical significance at P < 0.05 after Bonferroni correction (P < 0.000521) compared to a null model (two-sided test, H0: linear regression slope = 0). PGSs were tested in healthy participants from the Thematically Organized Psychosis study.
