Manhattan Plot from Scientific Research

Miami plot for MOSTest (orange) and min-P (blue), plotting for each SNP the -log 10 ( P ) against chromosomal position. By applying a multivariate framework which leverages pleiotropic effects, there is a substantial boost in signal compared to a 'mass univariate' approach such as min-P, evidenced by smaller P values and a larger number of discovered loci ( n = 431 versus 113). This indicates the presence of pleiotropic genetic effects across mental traits.

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