Chemical Structure from Scientific Research

Development of a bismuth-catalysed C–N cross-coupling reaction based on the oxidation of -amino alkyl radicals. a Standard reaction conditions: 22 (1 equiv.) and 25 (3 equiv.) in the presence of bismuthinidene 1 (10mol%) in DMA (0.033M) at 25C for 2h. Yields determined by 1 H NMR using diphenylmethane as internal standard. Ts, 4-toluenesulfonyl; Boc, tert -butoxycarbonyl.

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