Protein Structure from Scientific Research

PcIDS1 Mn:GPP:GPP (PDB 8A73); Mn 2+ A and Mn 2+ C sequester the PP Al moiety and prevent coordination of Mg 2+ D. A second GPP acts as an allosteric inhibitor (right). GPP is the main product of catalysis in the presence of Mn 2+ (left). Inhibition arrows are highlighted in black. Colour coding is described in the Methods.

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