Protein Structure from Scientific Research

Alignment of active site A with WT Mm PylRS bound to Pyl and AMP-PNP (PDB: 2ZCE , blue) 37 illustrates the difference between the water-mediated hydrogen bonds (orange dashes) to the α-amine of Pyl in PylRS compared with the direct carboxy-to-backbone hydrogen bonding of m -CF 3 -2-BMA bound to Ma FRSA.

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