Forest Plot from Scientific Research

Effect of CHIP on ADNC score in cognitively intact participants from ADSP stratified by APOE genotype. Participants were binned into those with neutral (APOE 33), low-risk (APOE 22 and 23) and high-risk (any APOE 4 allele) groups. ORs, CI95 and two-sided Wald P values were calculated for a six-point composite score of CERAD and Braak stages and analyzed using an ordinal logistic regression model with age at death, sex and CHIP carrier status as covariates (Supplementary Table 10 for full regression results). Adjustments for multiple comparisons were not performed. People, n = 422.

DOI