Comparison of models for aggressive disease, defined as Gleason score >=7, PSA >= 10 ng ml -1, T3–T4 stage and/or distant or nodal metastases in the SELECT. The pooled study population includes all ancestry groups. Logistic regression models were adjusted for baseline age, randomization arm, the top ten population-specific genetic ancestry principal components and proportions of African and East Asian genetic ancestry. ORs and 95% CIs were estimated per 1-unit increase in log(PSA ng ml -1 ) and log(PSA G ng ml -1 ) and per s.d. increase in the prostate cancer genetic risk score (PGS 269 ) from Conti et al. 32 , which was standardized to achieve s.d. equal to 1. All P values are two-sided. AUC is based on the full model with all covariates.
